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In terms of American lives that could be saved by policy changes, the difference between Sanders (or Warren) and Biden is significantly greater than between Biden & Trump. Medicare for All alone is over 60,000 per year. Zeroing out fossil fuels about half that.
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Looking beyond the US, wars in Yemen and possibly Iran loom, or could be taken off the table.
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We could legalize all 11 million undocumented immigrants or just the Dreamers. End ICE camps or "reform" them. End private prisons or keep them.
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We could universalize access to college and childcare, or decide our children and youth aren't worth it.